Chemotherapy, the most widely used against cancer, is a treatment method consisting of one or more drugs. Chemotherapy uses anticancer drugs to prevent or eliminate the growth and proliferation of cancer cells. Chemotherapy drugs may be administered by intravenous or intramuscular or orally. It can cause many side effects in the treatment process as it can damage normal cells other than cancer cells. The most common side effects are nausea, vomiting, hair loss, weakness and loss of appetite. In addition, there may be many serious side effects such as infection due to decreased immune cells and bleeding due to reduced clotting cells. You can ask your doctor about the methods that can be used to prevent these side effects.
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The medications that are used in the treatment of cancer is called chemotherapy; also anticancer drugs since they kill cancer cells. Chemotherapy can be applied before, during and after surgery and radiotherapy as well as used alone. More than one hundred chemotherapeutic drugs are currently being used.
Chemotherapy targets cells that are growing and dividing as rapidly as cancer cells do. The aim is to kill the cancer cells, prevent the progression of the cancer stage and the spread of cancer to the body, to relieve the patient by reducing the patient’s cancer related complaints, especially the pain.
Chemotherapy drugs are generally effective in preventing the proliferation of these cells by damaging various stages in the division of cancer cells with different methods. Success in the treatment of cancer has been increasing recently. Especially new smart drugs, directly affect cancer cell are satisfactory.
A chemotherapy session may only take a few hours, but its side effects can disrupt your life for days or weeks. You can reduce your frustrations by taking some precautions before treatment:
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The duration of treatment varies according to the medication, the type of cancer, the comorbidities and the response of the body to the treatment and the side effects. Each session of intravenous chemotherapy sometimes lasts only for half an hour and sometimes lasts 3-4 hours or several days. Hospitalization may be required for such a long-term treatment.
The number of sessions is determined before the start of chemotherapy treatment. The times between sessions and sessions are not always the same. It depends on the type of cancer, the response to the treatment and the side effects of the treatment.
Generally, the most commonly used intervals are 3-4 weeks, but some treatment schemes are once a week and every two weeks. The cancer cells can multiply again if the session intervals are kept long. This may lead to treatment failure.
There are dozens of chemotherapy drugs available for prescribtion. They are usually divided into groups according to their functions. Each group of medicines can destroy or reduce cancer cells in a different way.
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Drug selection is determined by the oncologist according to the type of cancer, prevalence, age, general condition and other diseases of the patient (high blood pressure, diabetes, heart disease, kidney disease).
The process of development and death of normal and healthy cells in the body is in an order and control. However, cancer cells grow and proliferate in an uncontrolled manner. Almost all of the chemotherapy drugs are delivered to the body through the bloodstream to reach the cells that are proliferating in an uncontrolled way, kill or prevent their growing.
They do this by acting their DNA and RNAs in a different way. In the meantime, damage to healthy cells and side effects occur. Adverse effects have been reduced with the recent introduction of smart drugs that directly targeting the cancer cells.
They may also cause long-term side effects such as kidney and heart failure, lung injury, nerve damage, infertility.
When the treatment plan is decided, detailed information should be obtained about the side effects may occur.
Chemotherapy drugs may cause nausea and vomiting by stimulating the vomiting center in the brain. This can be prevented by antiemetic drugs such as ondansetron and granisetron. In some cases steroid-derived drugs such as da dexamethasone are also used. Avoid bad smells which may trigger nausea. Different activities can be done to forget the feeling of nausea. It may also be beneficial to eat less, to eat slowly, not to nap immediately after meals and to prefer casual clothes.
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Since hair follicles are among the fast dividing cells, they are frequently affected by chemotherapy drugs. Generally, hair loss begins 2-3 weeks after treatment. Sometimes the color of the hair may change or the hairs in the body may loss. The severity of hair loss can vary depending on the dose, duration of the drug, and the presence of former hair loss. There is no need to demoralize after hair loss. Shortly after the treatment, the hair begins to grow again. Hats, wigs or headscarves can be worn. Choose nourishing shampoos during chemotherapy and do not brush your hair very often.
In the course of the treatment there may be redness, rash, dryness and darkening of the skin. The nails can easily break and the lines may form on them. During treatment, it is important to wear gloves when doing daily work, to protect from the sun and use sunscreen creams. The thickening of the skin usually passes after treatment.
During chemotherapy, the number of blood coagulating cells (platelets) may be reduced, causing to frequent bleeding. There may be active bleedings such as nasal bleeding, gum bleeding as well as subcutaneous bleedings such as bruising, redness. If there is blood in the urine, fecal hemorrhage or spot bleeding in the skin, a doctor should be consulted urgently. It is necessary to be careful when brushing teeth, protect the body as much as possible.
Some drugs irritate mouth, mouth sores may occur since the immune system weakens. This situation is called ’mucositis’ which causes dry mouth, weakening in the sensation of taste and bad smell of breath. You can protect your oral hygiene by gargling with salty or carbonated water. Mucositis passes a few weeks after the end of chemotherapy.
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Fatigue is one of the most common side effects of chemotherapy. You may even have difficulty in doing your daily work. Get help from friends or family. Do the activities that increase your energy. If you are working, you can get permission from your workplace for a while. If shortness of breath (dyspnea) develops with fatigue, anemia may have progressed. Be sure to consult a doctor.
Immune cells are produced in the bone marrow. Sometimes cancer itself, sometimes chemotherapy drugs, can reduce the immune cells by suppressing the bone marrow. In this case, the body cannot fight with bacteria good enough and cause illness.
After a few days of chemotherapy, constipation or diarrhea may develop. If the patient have severe diarrhea, fluid supplementation and medication can be initiated. As for constipation, medications, nutritional changes and an active life can help.
There is no specific dietary pattern when taking chemotherapy. The diet type is determined according to the patient, the side effects that may occur and the accompanying diseases of the patient. Since loss of appetite is a common side effect, a professional support may be received from dietitian before chemotherapy. Foods with high calories should be preferred for body resistance.
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Additional nutritional supplements can be used with the doctor’s recommendation. The patient should take plenty of fluids, eat smaller meals instead of large meals. Liver, meat, beans, walnuts, cereal foods, apricots and fiber foods would be beneficial.
Some drugs can cause infertility by damaging the sperm in a man and ovaries in women. This process can be temporary or permanent. If you have a child plan in the future, you can talk to the doctor and store the sperm before the chemotherapy.
Do not get pregnant while receiving chemotherapy. Drugs can harm the child. If you are diagnosed with cancer during pregnancy, discuss the pros and cons with your doctor and start treatment. Do not skip your controls. There may be a decrease or increase in sexual desire during chemotherapy. Males may have erection problem.
Drugs used in chemotherapy can interact with some drugs, foods and beverages. If you need to take medication during treatment or if you plan to take herbal or complementary medicine, be sure to consult your doctor. Chemotherapy drugs are marketed after the approval of the international authorities according to the results of clinical trials. There is no herbal remedy or alternative treatment that is used in cancer treatment.
It is recommended to have acupuncture, hypnotherapy and reflexology in order to prevent side effects such as nausea, vomiting and dry mouth due to chemotherapy. However, these treatments should be done by experts. Any application by non-specialists can cause cancer to spread elsewhere. Garlic with dacarbazine, soybean and flaxseed with tamoxifen, grapefruit, valerian root interact with numerous chemotherapy drugs.
During chemotherapy, patient can continue to work. However, treatment should be followed and controls should not be skipped. Excessive fatique may interfere with heavy workload. If the immune system is weak, working in crowded environments can increase your risk of infection.
You can go on vacation with permission from the doctor as far as you follow your treatment. However, the immune cells should be screened and coagulated cells should be measured. If you have problems with shortness of breath, you may need permission from the doctor to travel by plane.
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